Pilot Projects
The SC-ADRC Pilot Projects Program started in 2021 and offers one-year developmental grants to investigators who are interested in pursuing basic, clinical or translational research of Alzheimer’s disease and related dementias. This program supports innovative exploratory projects that are likely to lead to future funding through the National Institutes of Health or other similar mechanisms.
2024 Projects
“Validation of a Digital Phenotype for Alzheimer's Disease and Related Dementias in Electronic Health Records (EHR) and Medicare Data”
Sara Knox, PT, DPT, PhD
“AbE4 represents a novel and safer approach to mitigate prolonged inflammation, CAA and ARIA seen with Aducanumab treatment, with a major beneficial effect for APOE4 carriers”
Jose Ledo, PhD
“Investigate the effects of THC, oral microbiomes, and aging on Alzheimer’s Disease-related neuropathogenesis”
Rachel Penrod-Martin, PhD
2023 Projects
“Complement-Mediated Synaptic Degeneration and Tauopathy in TBI-related Dementia”
Onder Albayram, PhD
“Branching NF1 and VCP signaling transduction pathways into defined mechanisms for therapeutic approaches targeting aberrant dendritic morphology and neurite outgrowth”
Jody Longo, PhD
2021 Projects
“Bidirectional relationship between sleep and Aβ/tau pathology in Alzheimer’s disease model mice”
Takashi Sato, MD, PhD
“The Role of Fli-1 in Pericyte Dysfunction in Alzheimer’s Disease Development”
Hongkuan Fan, PhD
“TREM2 limits tau pathology”
Carsten Krieg, PhD
2025 Projects
“Exploring the Role of Neurodegenerative Biomarkers as Mechanisms and Moderators of Cognitive Training Effect”
Hye Won Chai, Ph.D., Abigail Stephan, Ph.D., Feng Ding, Ph.D., and Dariusz Pytel, Ph.D.
“Gait Variability and Control Complexity in Older Adults”
Reed Gurchiek, Ph.D.
“Interpretable Statistical and Machine Learning for Precision Medicine with Abundant Features in Alzheimer's Disease”
Xinyi Li, Ph.D.
“Interplay between Alzheimer's disease and cardiac dysfunction through Apolipoprotein E mutation”
Qing Liu, Ph.D.
“Advancing Precision Medicine for Alzheimer’s Disease and Related Dementia in Diverse Populations Using Artificial Intelligence and Machine Learning (AI/ML) Models”
Zahra Rahemi, Ph.D., RN
Morteza Sabet, Ph.D.
“Detecting cognitive decline in context: The role of everyday functioning and perceptions around health-tracking technologies”
Abigail Stephan, Ph.D.